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KMID : 0381219850170040271
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Journal of RIMSK
1985 Volume.17 No. 4 p.271 ~ p.278
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Recent Knowledge for the Cardioplegic Solution
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Abstract
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During open heart surgery, to prevent embolism and to obtain bloodless, quiet operative field, iatrogenic cardiac arrest is generally employed.
But the myocardial degeneration and necrosis is the great problem postoperatively.
To prevent such a myocardial injury during cardiac surgery, the concept of myocardial preservation was introduced.
Thereafter many kinds of cardioplegic solution were developed. However, the ideal cardioplegic solution is not yet found.
This article will review the recent knowledge about the cardioplegic solution in the view points of followings:
What is the optimal temperature of myocardium to protect from ischemia? How can one maintain diastolic arrest efficiently?
Is the oxygenated cardioplegic solution better than the crystalloid solution? How can one stabilize the myocardial cell membrane?
What is the optimal osmolarity of cardioplegic solution?
What is the optimal pH of cardioplegic solution?
Is the calcium channel blocker beneficial?
Is there any substance increasing energy store of myocardial cell?
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